Outstanding Challenges in Haemophilia B Research
Read the Astermark et al. Ther Adv Hematol 2026 publication
Much of haemophilia B care has been extrapolated from haemophilia A. This review highlights the molecular and clinical differences between FVIII and FIX that may influence disease phenotype, monitoring and treatment and identifies research priorities, from FIX biology and inhibitor risk to gaps in care for specific populations. It underscores the need for improved, disease-specific evidence to advance personalised care and achieve greater health equity in haemophilia B.
Abbreviations
FIX, Factor IX
FVIII, Factor VIII
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