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Tryngolza▼(olezarsen) is a monthly subcutaneous injection delivered via a convenient autoinjector1

The Tryngolza autoinjector

Tryngolza injector

Tryngolza may be injected into 1 of the following locations:1

tryngolza_injector_place_abdomen
tryngolza_injector_place_thigh
tryngolza_injector_place_upper_arm

Tryngolza should not be injected into skin that is bruised, tender, red, or hard, into scars or damaged skin; the area around the navel should be avoided.

If Tryngolza is stored in the refrigerator, it should be removed and allowed to warm up for 30 minutes in the original carton before injecting.

Three easy steps for injecting Tryngolza1

Wash your hands for 3 minutes with soap and dry them well, then clean the injection site with alcohol and let it dry. Do not touch the cleaned skin before injecting. Check the expiry date on the packaging and the appearance of the medicine before injecting. It should be clear and colourless or yellow.

Taking Tryngolza - place
Taking Tryngolza - push
Taking Tryngolza - hold

Do not lift the autoinjector until after holding for 10 seconds and checking that the orange plunger rod has filled the entire viewing window. Remove by lifting straight up, and throw away in a sharps container.

For additional information, please see complete Instructions for Use for Tryngolza.

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Your Tryngolza Treatment
PDF 3.2 MB 20 May 2026
Tryngolza Checklist
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Missed dose1

If a dose is missed:

  • Tryngolza should be administered as soon as possible after the missed dose
  • Resume dosing at monthly intervals from the date of the most recently administered dose

Not a real patient; actor portrayal.

Woman taking Tryngolza

Take Tryngolza on the go1

Store the autoinjector in the refrigerator between 2-8 °C in the original carton1

  • When removed from the refrigerator, the Tryngolza autoinjector can be stored at room temperature (between 15-30 ºC) 
in its original carton for up to 6 weeks1*
  • This allows patients to administer their once-monthly dose at home or away from home if necessary1

*If not used within the 6 weeks stored at room temperature, discard Tryngolza.1

Prior to initiation, train patients and/or caregivers on proper preparation and administration.1 For full details on administration and storage, see the instructions in the summary of product characteristics.

Not a real patient; actor portrayal.

Man with suitcase

Reference

  1. Tryngolza EU Summary of Product Characteristics. December 2025.

Tryngolza▼(olezarsen) is indicated as an adjunct to diet in adult patients for the treatment of genetically confirmed familial chylomicronemia syndrome (FCS).

▼This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. See section 4.8 of the SmPC for how to report adverse reactions.

Healthcare professionals should report any suspected adverse reactions via their national pharmacovigilance reporting system. Suspected adverse reactions should also be reported to Sobi via email at [email protected]. 

This material is intended for an international audience of healthcare professionals and is based on the Tryngolza Summary of Product Characteristics (SmPC) approved for use in the European Economic Area (EEA). SmPC/Prescribing information, product availability, and pricing/reimbursement conditions may vary by country. Before prescribing, always refer to locally approved SmPC and/or prescribing information.

Tryngolza SmPC

The Sobi Scientific Information Department is at your disposal for any additional information: [email protected]. 

© 2026 Sobi – Swedish Orphan Biovitrum AB (publ), SE-112 76 Stockholm, Sweden. www.sobi.com/en
All rights reserved. 
SOBI is a trademark of Swedish Orphan Biovitrum AB (publ).

TRYNGOLZA is a registered trademark of Arexis AB, a Sobi company, and Ionis Pharmaceuticals, Inc.
TRYNGOLZA (olezarsen) – Discovered by Ionis Pharmaceuticals, Inc.
All third-party trademarks are the property of their respective owners.

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